Lon plays the chaperone
نویسندگان
چکیده
منابع مشابه
Lon plays the chaperone
In This Issue In This Issue levels of exogenously expressed PRC1 caused unusual cytoplasmic arrays of microtubules in interphase cells. Overexpressed PRC1 bundles microtubules in interphase cells. Bundle up for cytokinesis ew results from Mollinari et al. (page 1175) reveal that cytokinesis requires microtubule bundles to be formed at the spindle midzone and that the mitotic spindle–associated ...
متن کاملPeroxisomal proteostasis involves a Lon family protein that functions as protease and chaperone.
Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln). We show that Pln is a heptameric protein and acts as an ATP-fueled protease and chaperone. Hence, Pln is the first chaperone identified in fungal peroxisomes....
متن کاملRoles of the N domain of the AAA+ Lon protease in substrate recognition, allosteric regulation and chaperone activity.
Degron binding regulates the activities of the AAA+ Lon protease in addition to targeting proteins for degradation. The sul20 degron from the cell-division inhibitor SulA is shown here to bind to the N domain of Escherichia coli Lon, and the recognition site is identified by cross-linking and scanning for mutations that prevent sul20-peptide binding. These N-domain mutations limit the rates of ...
متن کاملThe N-terminal domain plays a crucial role in the structure of a full-length human mitochondrial Lon protease
Lon is an essential, multitasking AAA(+) protease regulating many cellular processes in species across all kingdoms of life. Altered expression levels of the human mitochondrial Lon protease (hLon) are linked to serious diseases including myopathies, paraplegia, and cancer. Here, we present the first 3D structure of full-length hLon using cryo-electron microscopy. hLon has a unique three-dimens...
متن کاملNetwork Profiles for Lon
Standards are necessary for the successful interaction of field bus nodes. Because of the wide range of field bus applications, the Application Layer are very difficult to define. For the Local Operation Network (LON) detailed device specifications are already established by the LONMark standardisation organisation. This specifications focus on single devices especially. However, the relationsh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1577iti4